Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment

• Main Authors: Brian Sacks (Author), Halil Onal (Author), Rose Martorana (Author), Amogh Sehgal (Author), Amanda Harvey (Author), Catherine Wastella (Author), Hafsa Ahmad (Author), Erin Ross (Author), Adona Pjetergjoka (Author), Sachin Prasad (Author), Robert Barsotti (Author), Lindon H. Young (Author), Qian Chen (Author)
• Format: Book
• Published: BMC, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provide better protection against Dox than co-treatment. Methods We investiga...