KYA1797K, a Novel Small Molecule Destabilizing β-Catenin, Is Superior to ICG-001 in Protecting against Kidney Aging

• Main Authors: Mingsheng Zhu (Author), Xian Ling (Author), Shan Zhou (Author), Ping Meng (Author), Qiyan Chen (Author), Shuangqin Chen (Author), Kunyu Shen (Author), Chao Xie (Author), Yaozhong Kong (Author), Maosheng Wang (Author), Lili Zhou (Author)
• Format: Book
• Published: Karger Publishers, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Aged kidney is characterized by mitochondrial dysfunction, cellular senescence, and fibrogenesis. The activation of Wnt/β-catenin signaling plays an important role in the initiation of kidney aging. However, the inhibiting strategies have not been discovered in detail. Here, we compare...