Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism

Metabolic compartmentalization of stroma-rich tumors, like pancreatic ductal adenocarcinoma (PDAC), greatly contributes to malignancy. This involves cancer cells importing lactate from the microenvironment (reverse Warburg cells) through monocarboxylate transporter-1 (MCT1) along with substantial ph...

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Main Authors: Nourhane Ammar (Author), Maya Hildebrandt (Author), Claudia Geismann (Author), Christian Röder (Author), Timo Gemoll (Author), Susanne Sebens (Author), Ania Trauzold (Author), Heiner Schäfer (Author)
Format: Book
Published: MDPI AG, 2023-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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