Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti-PD1 therapy against melanoma

• Main Authors: Leyang Wu (Author), Lin Li (Author), Shufeng Li (Author), Lina Liu (Author), Wenjie Xin (Author), Chenyang Li (Author), Xingpeng Yin (Author), Xuebo Xu (Author), Feifei Bao (Author), Zichun Hua (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bacterial antitumor therapy has great application potential given its unique characteristics, including genetic manipulation, tumor targeting specificity and immune system modulation. However, the nonnegligible side effects and limited efficacy of clinical treatment limit their biomedical applicatio...