Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo

• المؤلفون الرئيسيون: Islam Saber Ead Mohamed (مؤلف), Aleksandra V. Sen'kova (مؤلف), Oleg V. Markov (مؤلف), Andrey V. Markov (مؤلف), Innokenty A. Savin (مؤلف), Marina A. Zenkova (مؤلف), Nadezhda L. Mironova (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the ribonuclease inhibitor (RI), resulting in the decre...