Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo

• Κύριοι συγγραφείς: Islam Saber Ead Mohamed (Συγγραφέας), Aleksandra V. Sen'kova (Συγγραφέας), Oleg V. Markov (Συγγραφέας), Andrey V. Markov (Συγγραφέας), Innokenty A. Savin (Συγγραφέας), Marina A. Zenkova (Συγγραφέας), Nadezhda L. Mironova (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2022-05-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the ribonuclease inhibitor (RI), resulting in the decre...