Identification of Potential Non-Systemic Therapeutics for Hyperammonemia

• Main Authors: Brad Nicklas (Author), Simon Velasquez Morales (Author), Jian Qian (Author), Kyle J. Stephens (Author), David R. Corbin (Author), Mark B. Shiflett (Author), Cory J. Berkland (Author), Alan M. Allgeier (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A non-absorbable therapeutic candidate for the treatment of hyperammonemia has been identified and characterized. Conventional approaches to reducing ammonia concentration in the blood and colon include acidifying the colon, inhibiting the bacterial production of ammonia, and activation of the urea...