Diverse actions of sirtuin-1 on ovulatory genes and cell death pathways in human granulosa cells

• Glavni autori: Jackson Sapuleni (Autor), Magdalena Szymanska (Autor), Rina Meidan (Autor)
• Format: Knjiga
• Izdano: BMC, 2022-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background Human granulosa-lutein cells (hGLCs) amply express sirtuin-1 (SIRT1), a NAD + -dependent deacetylase that is associated with various cellular functions. SIRT1 was shown to elevate cAMP on its own and additively with human chorionic gonadotropin (hCG), it is therefore interesting...