Cover Image

A<sub>3</sub> Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity

The overexpression of the A<sub>3</sub> adenosine receptor (AR) in a number of cancer cell types makes it an attractive target for tumor diagnosis and therapy. Hence, in the search for new A<sub>3</sub>AR ligands, a series of novel 2,<i>N</i><sup>6</sup&g...

Full description

Saved in:

Bibliographic Details
Main Authors:	Andrea Spinaci (Author), Michela Buccioni (Author), Diego Dal Ben (Author), Federica Maggi (Author), Gabriella Marucci (Author), Beatrice Francucci (Author), Giorgio Santoni (Author), Catia Lambertucci (Author), Rosaria Volpini (Author)
Format:	Book
Published:	MDPI AG, 2022-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview
by: Diego Dal Ben, et al.
Published: (2019)

"Dual Anta-Inhibitors" of the A<sub>2A</sub> Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies
by: Andrea Spinaci, et al.
Published: (2023)

P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications
by: Andrea Spinaci, et al.
Published: (2021)

Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors, and Efficacy in Animal Models of Depression
by: Flavia Varano, et al.
Published: (2021)

Tumor Immunotherapy Using A<sub>2A</sub> Adenosine Receptor Antagonists
by: Jinfeng Zhang, et al.
Published: (2020)

Adenosine Receptor Agonists Increase the Inhibition of Platelet Function by P2Y<sub>12</sub> Antagonists in a cAMP- and Calcium-Dependent Manner
by: Nina Wolska, et al.
Published: (2020)

Nucleoside Transport Inhibition by Dipyridamole Prevents Angiogenesis Impairment by Homocysteine and Adenosine
by: Antony Kam, et al.
Published: (2015)

Curcumin Stereoisomer, Cis-Trans Curcumin, as a Novel Ligand to A<sub>1</sub> and A<sub>3</sub> Adenosine Receptors
by: Luke J. Hamilton, et al.
Published: (2023)

Design and Synthesis of 2,6-Disubstituted-4'-Selenoadenosine-5'-<em>N</em>,<em>N</em>-Dimethyluronamide Derivatives as Human A<sub>3</sub> Adenosine Receptor Antagonists
by: Hongseok Choi, et al.
Published: (2021)

Species Differences in Microsomal Metabolism of Xanthine-Derived A<sub>1</sub> Adenosine Receptor Ligands
by: Daniela Schneider, et al.
Published: (2021)

Discovery of Novel Dual Adenosine A<sub>2A</sub> and A<sub>1</sub> Receptor Antagonists with 1<i>H</i>-Pyrazolo[3,4<i>-d</i>]pyrimidin-6-amine Core Scaffold as Anti-Parkinson's Disease Agents
by: Juyoung Jung, et al.
Published: (2022)

Preliminary Screening of South African Plants for Binding Affinity to the Serotonin Reuptake Transporter and Adenosine A<sub>1</sub>/A<sub>2A</sub> Receptors
by: Andisiwe Mnqika, et al.
Published: (2023)

Activation of Adenosine A<sub>1</sub> Receptor in Ischemic Stroke: Neuroprotection by Tetrahydroxy Stilbene Glycoside as an Agonist
by: Lingyu Ruan, et al.
Published: (2021)

Purinergic Ligands as Potential Therapeutic Tools for the Treatment of Inflammation-Related Intestinal Diseases
by: Diego Dal Ben, et al.
Published: (2018)

Guanidines: Synthesis of Novel Histamine H<sub>3</sub>R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect
by: Marek Staszewski, et al.
Published: (2023)

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A<sub>2B</sub> Receptor Binding Affinity
by: Marcel Lindemann, et al.
Published: (2021)

Effect of Adenosine Receptor Antagonists on Adenosine-Pretreated PC12 Cells Exposed to Paraquat
by: Liangcheng Shang, et al.
Published: (2022)

Requiem for Rimonabant: Therapeutic Potential for Cannabinoid CB<sub>1</sub> Receptor Antagonists after the Fall
by: Taryn Bosquez-Berger, et al.
Published: (2023)

Design, Synthesis, and Biological Evaluation of 4,4'-Difluorobenzhydrol Carbamates as Selective M<sub>1</sub> Antagonists
by: Jonas Kilian, et al.
Published: (2022)

BMS-986020, a Specific LPA<sub>1</sub> Antagonist, Provides Neuroprotection against Ischemic Stroke in Mice
by: Bhakta Prasad Gaire, et al.
Published: (2020)

Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A<sub>1 </sub>receptor activation
by: Zylka Mark J, et al.
Published: (2010)

Adenosine Increases the Immunosuppressive Capacity of Cervical Cancer Cells by Increasing PD-L1 Expression and TGF-β Production through Its Interaction with A<sub>2A</sub>R/A<sub>2B</sub>R
by: Rosario García-Rocha, et al.
Published: (2024)

BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease
by: Raymond Taylor, et al.
Published: (2016)

Impact of 5-HT<sub>3</sub> receptor antagonists on chemotherapy-induced nausea and vomiting: a retrospective cohort study
by: Lin Swu-Jane, et al.
Published: (2012)

Engineering the Surface of Ti<sub>3</sub>C<sub>2</sub> MXene Nanosheets for High Stability and Multimodal Anticancer Therapy
by: Chiranjeevi Korupalli, et al.
Published: (2022)

Quantitation of the A<sub>2A</sub> Adenosine Receptor Density in the Striatum of Mice and Pigs with [<sup>18</sup>F]FLUDA by Positron Emission Tomography
by: Daniel Gündel, et al.
Published: (2022)

Effects of the DL76 Antagonist/Inverse Agonist of Histamine H<sub>3</sub> Receptors on Experimental Periodontitis in Rats: Morphological Studies
by: Mariusz Geremek, et al.
Published: (2024)

Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists
by: Daniela Catarzi, et al.
Published: (2019)

New Diarylamine K<sub>V</sub>10.1 Inhibitors and Their Anticancer Potential
by: Špela Gubič, et al.
Published: (2022)

Nucleoside Modifications
Published: (2017)

Piperazine- and Piperidine-Containing Thiazolo[5,4-<i>d</i>]pyrimidine Derivatives as New Potent and Selective Adenosine A<sub>2A</sub> Receptor Inverse Agonists
by: Flavia Varano, et al.
Published: (2020)

Selective 5-HT<sub>6</sub> Receptor Ligands (Agonist and Antagonist) Show Different Effects on Antipsychotic Drug-Induced Metabolic Dysfunctions in Rats
by: Anna Partyka, et al.
Published: (2023)

Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT<sub>1A</sub> Serotonin Receptor Antagonists
by: Kinga Ostrowska, et al.
Published: (2021)

Radioimmune Imaging of α<sub>4</sub>β<sub>7</sub> Integrin and TNFα for Diagnostic and Therapeutic Applications in Inflammatory Bowel Disease
by: Alberto Signore, et al.
Published: (2023)

Biotransformation of ginsenosides Rb<sub>1</sub>, Rg<sub>3 </sub>and Rh<sub>2 </sub>in rat gastrointestinal tracts
by: Qian Tianxiu, et al.
Published: (2010)

H<sub>2</sub>O<sub>2</sub>/Ca<sup>2+</sup>/Zn<sup>2+</sup> Complex Can Be Considered a "Collaborative Sensor" of the Mitochondrial Capacity?
by: Ester Sara Di Filippo, et al.
Published: (2022)

Estudo da associação Li<sub>2</sub>CO<sub>3</sub> e adoçante não-calórico, C<sub>7</sub>H<sub>5</sub>NO<sub>3</sub>S, em células de medula óssea de camundongos
by: Juida de Deus Palma Contar, et al.
Published: (2008)

Development of the <sup>99m</sup>Tc-Labelled SST<sub>2</sub> Antagonist TECANT-1 for a First-in-Man Multicentre Clinical Study
by: Doroteja Novak, et al.
Published: (2023)

Adsorptive-Photocatalytic Performance for Antibiotic and Personal Care Product Using Cu<sub>0.5</sub>Mn<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub>
by: Chanat Chokejaroenrat, et al.
Published: (2023)

The Short Lipopeptides (C<sub>10</sub>)<sub>2</sub>-KKKK-NH<sub>2</sub> and (C<sub>12</sub>)<sub>2</sub>-KKKK-NH<sub>2</sub> Protect HaCaT Keratinocytes from Bacterial Damage Caused by <i>Staphylococcus aureus</i> Infection in a Co-Culture Model
by: Kirsten Reddersen, et al.
Published: (2020)