TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

• Main Authors: Karl Kunzelmann (Author), Jiraporn Ousingsawat (Author), Inês Cabrita (Author), Tereza Doušová (Author), Andrea Bähr (Author), Melanie Janda (Author), Rainer Schreiber (Author), Roberta Benedetto (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is dysfunctional in CF, leading to defects in epithelial...