Inhibition of Sodium-GlucoseCotransporter 2 with Dapagliflozin in Han: SPRD Rats with Polycystic Kidney Disease

• Main Authors: Daniel Rodriguez (Author), Sarika Kapoor (Author), Ilka Edenhofer (Author), Stephan Segerer (Author), Meliana Riwanto (Author), Anja Kipar (Author), Ming Yang (Author), Changlin Mei (Author), Rudolf P. Wüthrich (Author)
• Format: Book
• Published: Karger Publishers, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Dapagliflozin (DAPA) is a selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2) which induces glucosuria and osmotic diuresis. The therapeutic effect of DAPA in progressing stages of polycystic kidney disease (PKD) has not been studied. Methods: We examined the effect of...