Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors
The main protease (Mpro) of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life cycle. The covalent Mpro inhibitor nirmatrelvir (in combination with ritonavir, a pharmacokinetic enhancer) and the non-covalent inhibitor ensitrelvir ha...
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Main Authors: | , , , , , , , , , , , |
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Format: | Book |
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Elsevier,
2024-01-01T00:00:00Z.
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A1234.567 |
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