Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors

The main protease (Mpro) of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy for its high conservation and major role in the virus life cycle. The covalent Mpro inhibitor nirmatrelvir (in combination with ritonavir, a pharmacokinetic enhancer) and the non-covalent inhibitor ensitrelvir ha...

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Main Authors: Letian Song (Author), Shenghua Gao (Author), Bing Ye (Author), Mianling Yang (Author), Yusen Cheng (Author), Dongwei Kang (Author), Fan Yi (Author), Jin-Peng Sun (Author), Luis Menéndez-Arias (Author), Johan Neyts (Author), Xinyong Liu (Author), Peng Zhan (Author)
Format: Book
Published: Elsevier, 2024-01-01T00:00:00Z.
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