The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins

• Main Authors: Huanbiao Mo (Author), Rayna Jeter (Author), Andrea Bachmann (Author), Sophie T. Yount (Author), Chwan-Li Shen (Author), Hoda Yeganehjoo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mevalonate pathway provides sterols for membrane structure and nonsterol intermediates for the post-translational modification and membrane anchorage of growth-related proteins, including the Ras, Rac, and Rho GTPase family. Mevalonate-derived products are also essential for the Hedgehog pathway...