Loricrin and NRF2 Coordinate Cornification

• Main Authors: Yosuke Ishitsuka (Author), Tatsuya Ogawa (Author), Yoshiyuki Nakamura (Author), Noriko Kubota (Author), Yasuhiro Fujisawa (Author), Rei Watanabe (Author), Naoko Okiyama (Author), Manabu Fujimoto (Author), Dennis R. Roop (Author), Akemi Ishida-Yamamoto (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cornification involves cytoskeletal cross-linkages in corneocytes (the brick) and the secretion of lipids/adhesion structures to the interstitial space (the mortar). Because the assembly of lipid envelopes precedes corneocyte maturation, loricrin is supposed to be dispensable for the protection agai...