In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [¹¹C]OCM-44 and [¹⁸F]OCM-50 in Non-Human Primates

• Main Authors: Kelly Smart (Author), Ming-Qiang Zheng (Author), Daniel Holden (Author), Zachary Felchner (Author), Li Zhang (Author), Yanjiang Han (Author), Jim Ropchan (Author), Richard E. Carson (Author), Neil Vasdev (Author), Yiyun Huang (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glycogen synthase kinase 3 (GSK-3) is a potential therapeutic target for a range of neurodegenerative and psychiatric disorders. The goal of this work was to evaluate two leading GSK-3 positron emission tomography (PET) radioligands, [¹¹C]OCM-44 and [¹⁸F...