The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis.

• Main Authors: Rebecca L Renberg (Author), Xiaojing Yuan (Author), Tamika K Samuel (Author), Danilo C Miguel (Author), Iqbal Hamza (Author), Norma W Andrews (Author), Andrew R Flannery (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania spp. are trypanosomatid parasites that replicate intracellularly in macrophages, causing serious human morbidity and mortality throughout the world. Trypanosomatid protozoa cannot synthesize heme, so must acquire this essential cofactor from their environment. Earlier studies identified L...