The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis.

• Главные авторы: Rebecca L Renberg (Автор), Xiaojing Yuan (Автор), Tamika K Samuel (Автор), Danilo C Miguel (Автор), Iqbal Hamza (Автор), Norma W Andrews (Автор), Andrew R Flannery (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2015-05-01T00:00:00Z.
• Предметы: article
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Leishmania spp. are trypanosomatid parasites that replicate intracellularly in macrophages, causing serious human morbidity and mortality throughout the world. Trypanosomatid protozoa cannot synthesize heme, so must acquire this essential cofactor from their environment. Earlier studies identified L...