Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1α/VEGF/TFEB-Activated Angiogenesis

• Autors principals: Runfang Zhang (Autor), Tingkui Zhao (Autor), Beibei Zheng (Autor), Yun Zhang (Autor), Xiaohui Li (Autor), Feng Zhang (Autor), Juan Cen (Autor), Shaofeng Duan (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

In this paper, a curcumin derivative Cur20 was synthesized for better hydrolytic stability, which showed a higher angiogenic effect on zebrafish model than curcumin. In order to reveal the potential effects on neuroprotection, a mouse model of vascular dementia (VaD) induced by permanent right commo...