Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency

• Main Authors: Juanjuan Liu (Author), Yifei Geng (Author), Su Jiang (Author), Lixia Guan (Author), Junyi Gao (Author), Miao-Miao Niu (Author), Jindong Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given that overexpression of Poly (ADP-ribose) polymerase-1 (PARP1) and Neuropilin-1 (NRP1) is implicated in the pathogenesis of human breast cancer, the design of dual PARP1/NRP1 inhibitors has wide therapeutic prospect. However, there have been no reports of such inhibitors so far. Herein, we disc...