Discovery of novel PARP1/NRP1 dual-targeting inhibitors with strong antitumor potency

• Príomhchruthaitheoirí: Juanjuan Liu (Údar), Yifei Geng (Údar), Su Jiang (Údar), Lixia Guan (Údar), Junyi Gao (Údar), Miao-Miao Niu (Údar), Jindong Li (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Given that overexpression of Poly (ADP-ribose) polymerase-1 (PARP1) and Neuropilin-1 (NRP1) is implicated in the pathogenesis of human breast cancer, the design of dual PARP1/NRP1 inhibitors has wide therapeutic prospect. However, there have been no reports of such inhibitors so far. Herein, we disc...