p53 Forms Redox-Dependent Protein-Protein Interactions through Cysteine 277

• Main Authors: Tao Shi (Author), Paulien E. Polderman (Author), Marc Pagès-Gallego (Author), Robert M. van Es (Author), Harmjan R. Vos (Author), Boudewijn M. T. Burgering (Author), Tobias B. Dansen (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reversible cysteine oxidation plays an essential role in redox signaling by reversibly altering protein structure and function. Cysteine oxidation may lead to intra- and intermolecular disulfide formation, and the latter can drastically stabilize protein-protein interactions in a more oxidizing mili...