Positional scanning of natural product hispidol's ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases

• Main Authors: Ahmed H. E. Hassan (Author), Hyeon Jeong Kim (Author), Min Sung Gee (Author), Jong-Hyun Park (Author), Hye Rim Jeon (Author), Cheol Jung Lee (Author), Yeonwoo Choi (Author), Suyeon Moon (Author), Danbi Lee (Author), Jong Kil Lee (Author), Ki Duk Park (Author), Yong Sup Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multifunctional molecules might offer better treatment of complex multifactorial neurological diseases. Monoaminergic pathways dysregulation and neuroinflammation are common convergence points in diverse neurodegenerative and neuropsychiatric disorders. Aiming to target these diseases, polypharmacol...