CYP2C19 genotypes and osteoporotic fractures in long‐term users of proton pump inhibitors: A hospital‐based study

• Main Authors: Yi‐Ju Liao (Author), Yu‐Ting Chen (Author), Tzu‐Hung Hsiao (Author), Ching‐Heng Lin (Author), Ming‐Fen Wu (Author), Chiann‐Yi Hsu (Author), Yi‐Ming Chen (Author), Chun‐Sheng Hsu (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Proton pump inhibitors (PPIs) are commonly prescribed medications. The existing data suggest that individuals at a high risk of fractures have been exposed to high doses of PPIs for prolonged durations. CYP2C19 plays a pivotal role in metabolism of PPIs and thereby influences their pharmaco...