Population Pharmacodynamic Modelling of the CD19+ Suppression Effects of Rituximab in Paediatric Patients with Neurological and Autoimmune Diseases

• Main Authors: Natalia Riva (Author), Lucas Brstilo (Author), Aymara Sancho-Araiz (Author), Manuel Molina (Author), Andrea Savransky (Author), Georgina Roffé (Author), Marianela Sanz (Author), Silvia Tenembaum (Author), Maria M. Katsicas (Author), Iñaki F. Trocóniz (Author), Paula Schaiquevich (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Limited pharmacotherapy and the failure of conventional treatments in complex pathologies in children lead to increased off-label use of rituximab. We aimed to characterize the time course of CD19+ B lymphocytes (CD19+) under treatment with intravenous rituximab in children with neurolog...