First description of the katG gene deletion in a Mycobacterium tuberculosis clinical isolate and its impact on the mycobacterial fitness

• Main Authors: Flavio De Maio (Author), Antonella Cingolani (Author), Delia Mercedes Bianco (Author), Alessandro Salustri (Author), Ivana Palucci (Author), Maurizio Sanguinetti (Author), Giovanni Delogu (Author), Michela Sali (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isoniazid (INH) is the cornerstone of the anti-tuberculosis regimens and emergence of Mycobacterium tuberculosis (Mtb) resistant strains is a major threat to our ability to control tuberculosis (TB) at global level. Mutations in the gene coding the catalase KatG confer resistance to high level of IN...