Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

• Main Authors: Shaoyong Lu (Author), Yingyi Chen (Author), Jiacheng Wei (Author), Mingzhu Zhao (Author), Duan Ni (Author), Xinheng He (Author), Jian Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase, sirtuin 6 (SIRT6) has attracted interest and presents a pharmaceutical target for aging-related and cancer diseases. However, the mechanism underlying allosteric activation of...