Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice

• Główni autorzy: Mingxing Wang (Autor), Bo Wu (Autor), Sapana N. Shah (Autor), Peijuan Lu (Autor), Qilong Lu (Autor)
• Format: Książka
• Wydane: Elsevier, 2019-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy, with ongoing clinical trials. However, therapeutic applications of AOs remain limited, particularly because of the lack of efficient cellular delivery methods imperative for achieving efficacy. In...