Gabapentin Modulates HCN4 Channel Voltage-Dependence

• Main Authors: Han-Shen Tae (Author), Kelly M. Smith (Author), A. Marie Phillips (Author), Kieran A. Boyle (Author), Melody Li (Author), Ian C. Forster (Author), Robert J. Hatch (Author), Robert Richardson (Author), David I. Hughes (Author), Brett A. Graham (Author), Steven Petrou (Author), Christopher A. Reid (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gabapentin (GBP) is widely used to treat epilepsy and neuropathic pain. There is evidence that GBP can act on hyperpolarization-activated cation (HCN) channel-mediated Ih in brain slice experiments. However, evidence showing that GBP directly modulates HCN channels is lacking. The effect of GBP was...