Sensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studies

• Үндсэн зохиолчид: Salla Valtonen (Зохиогч), Emmiliisa Vuorinen (Зохиогч), Ville Eskonen (Зохиогч), Morteza Malakoutikhah (Зохиогч), Kari Kopra (Зохиогч), Harri Härmä (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Protein aggregation is a spontaneous process affected by multiple external and internal properties, such as buffer composition and storage temperature. Aggregation of protein-based drugs can endanger patient safety due, for example, to increased immunogenicity. Aggregation can also inactivate protei...