Sensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studies

• Main Authors: Salla Valtonen (Author), Emmiliisa Vuorinen (Author), Ville Eskonen (Author), Morteza Malakoutikhah (Author), Kari Kopra (Author), Harri Härmä (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein aggregation is a spontaneous process affected by multiple external and internal properties, such as buffer composition and storage temperature. Aggregation of protein-based drugs can endanger patient safety due, for example, to increased immunogenicity. Aggregation can also inactivate protei...