Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors

• Main Authors: Weize Huang (Author), Felix Stader (Author), Phyllis Chan (Author), Colby S. Shemesh (Author), Yuan Chen (Author), Katherine L. Gill (Author), Hannah M. Jones (Author), Linzhong Li (Author), Gianluca Rossato (Author), Benjamin Wu (Author), Jin Y. Jin (Author), Pascal Chanu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Atezolizumab has been studied in multiple indications for both pediatric and adult patient populations. Generally, clinical studies enrolling pediatric patients may not collect sufficient pharmacokinetic data to characterize the drug exposure and disposition because of operational, ethic...