AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice

• Үндсэн зохиолчид: Lionel Carneiro (Зохиогч), Mohamed Asrih (Зохиогч), Cendrine Repond (Зохиогч), Christine Sempoux (Зохиогч), Jean-Christophe Stehle (Зохиогч), Corinne Leloup (Зохиогч), François R. Jornayvaz (Зохиогч), Luc Pellerin (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2017-12-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objective: Hepatic steatosis is the first step leading to non-alcoholic fatty liver disease, which represents a major complication of obesity. Here, we show that MCT1 haploinsufficient mice resist to hepatic steatosis development when fed a high fat diet. They exhibit a reduced hepatic capacity to m...