AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice

• Main Authors: Lionel Carneiro (Author), Mohamed Asrih (Author), Cendrine Repond (Author), Christine Sempoux (Author), Jean-Christophe Stehle (Author), Corinne Leloup (Author), François R. Jornayvaz (Author), Luc Pellerin (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hepatic steatosis is the first step leading to non-alcoholic fatty liver disease, which represents a major complication of obesity. Here, we show that MCT1 haploinsufficient mice resist to hepatic steatosis development when fed a high fat diet. They exhibit a reduced hepatic capacity to m...