Augmented Therapeutic Potential of Glutaminase Inhibitor CB839 in Glioblastoma Stem Cells Using Gold Nanoparticle Delivery

• मुख्य लेखकों: Beatriz Giesen (लेखक), Ann-Christin Nickel (लेखक), Juri Barthel (लेखक), Ulf Dietrich Kahlert (लेखक), Christoph Janiak (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Gold nanoparticles (Au NPs) are studied as delivery systems to enhance the effect of the glutaminase1 inhibitor CB839, a promising drug candidate already in clinical trials for tumor treatments. Au NPs were synthesized using a bottom-up approach and covered with polymers able to bind CB839 as a Au-p...