Cyclosporin A Decreases Human Macrophage Interleukin-6 Synthesis at Post-Transcriptional Level

• Main Authors: Juan E. Losa García (Author), Ana M. Rodríguez López (Author), María Rosa Martín De Cabo (Author), Fernando Mateos Rodríguez (Author), Jesús Pérez Losada (Author), Rogelio González Sarmiento (Author), Antonio Jiménez López (Author), José Luis Pérez Arellano (Author)
• Format: Book
• Published: Hindawi Limited, 1999-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In addition to its well-established effect on T cells, cyclosporin A (CsA) also inhibits inflammatory cytokine production by macrophages. However, little is known about the mechanism of action of CsA on macrophage cytokine production. We measured the effect of CsA on basal and phorbol-myristate-acet...