Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the <i>Ent</i>-Morphinan Pharmacophore of Tazopsine-Type Alkaloids

• Main Authors: Antoinette Keita (Author), Jean-François Franetich (Author), Maëlle Carraz (Author), Loïse Valentin (Author), Mallaury Bordessoules (Author), Ludivine Baron (Author), Pierre Bigeard (Author), Florian Dupuy (Author), Valentine Geay (Author), Maurel Tefit (Author), Véronique Sarrasin (Author), Sylvie Michel (Author), Catherine Lavazec (Author), Sandrine Houzé (Author), Dominique Mazier (Author), Valérie Soulard (Author), François-Hugues Porée (Author), Romain Duval (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The alkaloid tazopsine <b>1</b> was introduced in the late 2000s as a novel antiplasmodial hit compound active against <i>Plasmodium falciparum</i> hepatic stages, with the potential to develop prophylactic drugs based on this novel chemical scaffold. However, the structural...