Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury

• Main Authors: Adam J. Rauckhorst (Author), Gabriela Vasquez Martinez (Author), Gabriel Mayoral Andrade (Author), Hsiang Wen (Author), Ji Young Kim (Author), Aaron Simoni (Author), Claudia Robles-Planells (Author), Kranti A. Mapuskar (Author), Prerna Rastogi (Author), Emily J. Steinbach (Author), Michael L. McCormick (Author), Bryan G. Allen (Author), Navjot S. Pabla (Author), Ashley R. Jackson (Author), Mitchell C. Coleman (Author), Douglas R. Spitz (Author), Eric B. Taylor (Author), Diana Zepeda-Orozco (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Energy-intensive kidney reabsorption processes essential for normal whole-body function are maintained by tubular epithelial cell metabolism. Although tubular metabolism changes markedly following acute kidney injury (AKI), it remains unclear which metabolic alterations are beneficial or...