How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

• Main Authors: Stephan Wullschleger (Author), Kei Sakamoto (Author), Lana Johnstone (Author), Suzanne Duce (Author), Stewart Fleming (Author), Dario R. Alessi (Author)
• Format: Book
• Published: The Company of Biologists, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY The Akt signalling pathway plays vital roles in controlling cellular responses to insulin as well as in proliferation and survival. Inhibition of Akt signalling leads to insulin resistance and type 2 diabetes, whereas hyperactivation of Akt promotes tumorigenesis. In this study, we investiga...