Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism.

• Main Authors: Adriana S A Pereira (Author), Murilo S Amaral (Author), Elton J R Vasconcelos (Author), David S Pires (Author), Huma Asif (Author), Lucas F daSilva (Author), David A Morales-Vicente (Author), Vitor C Carneiro (Author), Claudia B Angeli (Author), Giuseppe Palmisano (Author), Marcelo R Fantappie (Author), Raymond J Pierce (Author), João C Setubal (Author), Sergio Verjovski-Almeida (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The possibility of emergence of praziquantel-resistant Schistosoma parasites and the lack of other effective drugs demand the discovery of new schistosomicidal agents. In this context the study of compounds that target histone-modifying enzymes is extremely promising. Our aim was to inves...