Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

• Main Authors: Rodrigo Azevedo Loiola (Author), Johan Hachani (Author), Sophie Duban-Deweer (Author), Emmanuel Sevin (Author), Paulina Bugno (Author), Agnieszka Kowalska (Author), Eleonora Rizzi (Author), Fumitaka Shimizu (Author), Takashi Kanda (Author), Caroline Mysiorek (Author), Maciej Mazurek (Author), Fabien Gosselet (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects. We therefore tested the hypothesis that secretome of these cells might be used instead to still fo...