Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities

Novel quinazolinones conjugated with indole acetamide (4a-c), ibuprofen (7a-e), or thioacetohydrazide (13a,b, and 14a-d) were designed to increase COX-2 selectivity. The three synthesised series exhibited superior COX-2 selectivity compared with the previously reported quinazolinones and their NSAID...

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Main Authors: Asmaa Sakr (Author), Samar Rezq (Author), Samy M. Ibrahim (Author), Eman Soliman (Author), Mohamed M. Baraka (Author), Damian G. Romero (Author), Hend Kothayer (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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