Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics

• Main Authors: Florian Heinkel (Author), Meghan M. Verstraete (Author), Siran Cao (Author), Janessa Li (Author), Patrick Farber (Author), Elizabeth Stangle (Author), Begonia Silva-Moreno (Author), Fangni Peng (Author), Surjit Dixit (Author), Martin J. Boulanger (Author), Thomas Spreter Von Kreudenstein (Author), Eric Escobar-Cabrera (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunoglobulin G (IgG) has served as a traditional framework for antibody-based biology, and engineering approaches for creating multispecific therapeutics have greatly expanded its applicability. Despite these developments, there are limits to the functionality of IgG with respect to effector cells...