P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease

• Main Authors: Yanzhen Li (Author), Hong Zhang (Author), Jingwen Yang (Author), Muouyang Zhan (Author), Xuefei Hu (Author), Yongmin Liu (Author), Lingling Yu (Author), Xiaochen Yan (Author), Shangdong Liang (Author), Ruyue Zhang (Author), Ying Lu (Author), Beining Li (Author), Cunzhi Liu (Author), Man Li (Author)
• Format: Book
• Published: BMC, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The P2Y12 receptor is a kind of purinoceptor that is engaged in platelet aggregation, and P2Y12 inhibitors have been used in clinical antithrombotic therapy. The P2Y12 receptor in microglia induces interleukin-1β (IL-1β) expression, which is a key mediator of depression in the br...