Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response

• Main Authors: Cécile Guth (Author), Pia Philippa Schumacher (Author), Archena Vijayakumar (Author), Hannah Borgmann (Author), Helene Balles (Author), Marianne Koschel (Author), Frederic Risch (Author), Benjamin Lenz (Author), Achim Hoerauf (Author), Marc P. Hübner (Author), Jesuthas Ajendra (Author)
• Format: Book
• Published: Karger Publishers, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Interleukin-4 (IL-4) is a central regulator of type 2 immunity, crucial for the defense against multicellular parasites like helminths. This study focuses on its roles and cellular sources during Litomosoides sigmodontis infection, a model for human filarial infections. Methods: Utiliz...