CRISPR/Cas9-Mediated Three Nucleotide Insertion Corrects a Deletion Mutation in MRP1/ABCC1 and Restores Its Proper Folding and Function

A three-nucleotide deletion in cystic fibrosis transmembrane conductance regulator/ATP-binding cassette transporter C7 (CFTR/ABCC7) resulting in the absence of phenylalanine at 508 leads to mis-fold of the mutated protein and causes cystic fibrosis. We have used a comparable three-nucleotide deletio...

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Bibliographic Details
Main Authors: Qinqin Xu (Author), Yue-xian Hou (Author), Xiu-bao Chang (Author)
Format: Book
Published: Elsevier, 2017-06-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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