Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis

• Main Authors: Zuoxing Wu (Author), Xuedong Li (Author), Xiaohui Chen (Author), Xuemei He (Author), Yu Chen (Author), Long Zhang (Author), Zan Li (Author), Mengyu Yang (Author), Guixin Yuan (Author), Baohong Shi (Author), Ning Chen (Author), Na Li (Author), Haotian Feng (Author), Mengyu Zhou (Author), Gang Rui (Author), Feng Xu (Author), Ren Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A major complication of a joint replacement is prosthesis loosening caused by inflammatory osteolysis, leading to the revision of the operation. This is due to the abnormal activation of osteoclast differentiation and function caused by periprosthetic infection. Therefore, targeting abnormally activ...