Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis

• Главные авторы: Zuoxing Wu (Автор), Xuedong Li (Автор), Xiaohui Chen (Автор), Xuemei He (Автор), Yu Chen (Автор), Long Zhang (Автор), Zan Li (Автор), Mengyu Yang (Автор), Guixin Yuan (Автор), Baohong Shi (Автор), Ning Chen (Автор), Na Li (Автор), Haotian Feng (Автор), Mengyu Zhou (Автор), Gang Rui (Автор), Feng Xu (Автор), Ren Xu (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

A major complication of a joint replacement is prosthesis loosening caused by inflammatory osteolysis, leading to the revision of the operation. This is due to the abnormal activation of osteoclast differentiation and function caused by periprosthetic infection. Therefore, targeting abnormally activ...