Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function

• मुख्य लेखकों: Amy S. Findlay (लेखक), Roderick N. Carter (लेखक), Becky Starbuck (लेखक), Lisa McKie (लेखक), Klára Nováková (लेखक), Peter S. Budd (लेखक), Margaret A. Keighren (लेखक), Joseph A. Marsh (लेखक), Sally H. Cross (लेखक), Michelle M. Simon (लेखक), Paul K. Potter (लेखक), Nicholas M. Morton (लेखक), Ian J. Jackson (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2018-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Isocitrate dehydrogenase (IDH) is an enzyme required for the production of α-ketoglutarate from isocitrate. IDH3 generates the NADH used in the mitochondria for ATP production, and is a tetramer made up of two α, one β and one γ subunit. Loss-of-function and missense mutations in both IDH3A and IDH3...