Comparison of Seven Non-Linear Mixed Effect Model-Based Approaches to Test for Treatment Effect

• Main Authors: Estelle Chasseloup (Author), Mats O. Karlsson (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Analyses of longitudinal data with non-linear mixed-effects models (NLMEM) are typically associated with high power, but sometimes at the cost of inflated type I error. Approaches to overcome this problem were published recently, such as model-averaging across drug models (MAD), individual model-ave...