Altered Mitochondrial Opa1-Related Fusion in Mouse Promotes Endothelial Cell Dysfunction and Atherosclerosis

• Main Authors: Ahmad Chehaitly (Author), Anne-Laure Guihot (Author), Coralyne Proux (Author), Linda Grimaud (Author), Jade Aurrière (Author), Benoit Legouriellec (Author), Jordan Rivron (Author), Emilie Vessieres (Author), Clément Tétaud (Author), Antonio Zorzano (Author), Vincent Procaccio (Author), Françoise Joubaud (Author), Pascal Reynier (Author), Guy Lenaers (Author), Laurent Loufrani (Author), Daniel Henrion (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flow (shear stress)-mediated dilation (FMD) of resistance arteries is a rapid endothelial response involved in tissue perfusion. FMD is reduced early in cardiovascular diseases, generating a major risk factor for atherosclerosis. As alteration of mitochondrial fusion reduces endothelial cells'...