Rational fusion design inspired by cell-penetrating peptide: SS31/S-14 G Humanin hybrid peptide with amplified multimodal efficacy and bio-permeability for the treatment of Alzheimer's disease

• Main Authors: Kang Qian (Author), Peng Yang (Author), Yixian Li (Author), Ran Meng (Author), Yunlong Cheng (Author), Lingling Zhou (Author), Jing Wu (Author), Shuting Xu (Author), Xiaoyan Bao (Author), Qian Guo (Author), Pengzhen Wang (Author), Minjun Xu (Author), Dongyu Sheng (Author), Qizhi Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease is a neurodegenerative disease induced by multiple interconnected mechanisms. Peptide drug candidates with multi-modal efficacy generated from fusion strategy are suitable for addressing multi-facet pathology. However, clinical translation of peptide drugs is greatly hampere...