Population Pharmacokinetics and Significant Under-Dosing of Anti-Tuberculosis Medications in People with HIV and Critical Illness

• Main Authors: Prakruti S. Rao (Author), Christopher C. Moore (Author), Amir A. Mbonde (Author), Edwin Nuwagira (Author), Patrick Orikiriza (Author), Dan Nyehangane (Author), Mohammad H. Al-Shaer (Author), Charles A. Peloquin (Author), Jean Gratz (Author), Suporn Pholwat (Author), Rinah Arinaitwe (Author), Yap Boum (Author), Juliet Mwanga-Amumpaire (Author), Eric R. Houpt (Author), Leonid Kagan (Author), Scott K. Heysell (Author), Conrad Muzoora (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Critical illness from tuberculosis (TB) bloodstream infection results in a high case fatality rate for people living with human immunodeficiency virus (HIV). Critical illness can lead to altered pharmacokinetics and suboptimal drug exposures. We enrolled adults living with HIV and hospitalized with...