Assessing CYP2C19 Ontogeny in Neonates and Infants Using Physiologically Based Pharmacokinetic Models: Impact of Enzyme Maturation Versus Inhibition

• Main Authors: Peng Duan (Author), Fang Wu (Author), Jason N. Moore (Author), Jeffrey Fisher (Author), Victor Crentsil (Author), Daniel Gonzalez (Author), Lei Zhang (Author), Gilbert J. Burckart (Author), Jian Wang (Author)
• Format: Book
• Published: Wiley, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this study was to develop pediatric physiologically based pharmacokinetic (PBPK) models for pantoprazole and esomeprazole. Pediatric PBPK models were developed by Simcyp version 15 by incorporating cytochrome P450 (CYP)2C19 maturation and auto‐inhibition. The predicted‐to‐observed p...