Mechanism of action of paclitaxel for treating glioblastoma based on single-cell RNA sequencing data and network pharmacology

• Main Authors: Jianglong Lu (Author), Fanjie Xu (Author), Changjun Rao (Author), Chaodong Shen (Author), Jinghao Jin (Author), Zhangzhang Zhu (Author), Chengde Wang (Author), Qun Li (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Paclitaxel is an herbal active ingredient used in clinical practice that shows anti-tumor effects. However, its biological activity, mechanism, and cancer cell-killing effects remain unknown. Information on the chemical gene interactions of paclitaxel was obtained from the Comparative Toxicogenomics...