P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice

• Main Authors: Vinícius Santos Alves (Author), Joyce Pereira da Silva (Author), Fabiana Cristina Rodrigues (Author), Suzana Maria Bernardino Araújo (Author), André Luiz Gouvêa (Author), Raíssa Leite-Aguiar (Author), Stephanie Alexia Cristina Silva Santos (Author), Milla Souza Pessoa da Silva (Author), Fernanda Silva Ferreira (Author), Eduardo Peil Marques (Author), Beatriz Amanda Barbosa Rangel dos Passos (Author), Tatiana Maron-Gutierrez (Author), Eleonora Kurtenbach (Author), Robson da Costa (Author), Cláudia Pinto Figueiredo (Author), Angela T. S. Wyse (Author), Robson Coutinho-Silva (Author), Luiz Eduardo Baggio Savio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Sepsis is defined as a multifactorial debilitating condition with high risks of death. The intense inflammatory response causes deleterious effects on the brain, a condition called sepsis-associated encephalopathy. Neuroinflammation or pathogen recognition are able to stress cells, res...