Physicochemical characterisation of spray dried ternary solid dispersions of simvastatin. Processability, tableting and dissolution

• Main Authors: Hanan Abdalmaula (Author), Anant Paradkar (Author), Krzysztof J Paluch (Author)
• Formato: Libro
• Publicado: University of Huddersfield Press, 2019-04-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Simvastatin(SMV) is poorly soluble drug classified as belonging to Class II of Biopharmaceutics Classification System. Common approach to improve apparent solubility of drugs is production of amorphous solid dispersions (ASD) by means of spray drying(SD) or hot-melt extrusion. Spray drying of low-gl...